Rapamycin
InvestigationalAlso known as: Sirolimus, mTOR inhibitor
mTOR inhibitor (macrolide)
- How it works
- Inhibits the mTOR pathway involved in cell growth and metabolism. FDA-approved as an immunosuppressant; its use for longevity/healthspan is investigational and off-label.
- Known risks
- Immunosuppression and infection risk, mouth sores, metabolic changes (lipids, glucose); longevity-context risk/benefit is not established.
- Contraindications
- Active infection; pregnancy; known hypersensitivity; settings where immunosuppression is unsafe.
- Drug interactions
- Levels strongly affected by CYP3A4/P-gp inhibitors and inducers; many clinically significant interactions.
Citations
- mTOR inhibition improves immune function in the elderly (RAD001 trial) (2014) · PMID 25540326
This information is educational only and is not medical advice. A licensed provider makes all clinical decisions. Diadara provides no dosing, reconstitution, or administration guidance.
Rapamycin is provided here for education only — it is not currently offered through Diadara. See what we do offer →
